GC/MS Quantitation of Benzoylecgonine Following Liquid-Liquid Extraction of Urine

    Volume 38, Issue 5 (September 1993)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Page Count: 5


    Gerlits, J
    Criminalist, Utah State Crime Lab, Southern Utah University, Cedar City, UT

    (Received 5 June 1992; accepted 12 February 1993)

    Abstract

    An analytical procedure for the determination of benzoylecgonine in urine by GC/MS using a two step liquid-liquid extraction scheme has been developed. Benzoylecgonine is one of the principle metabolites of cocaine. The extraction uses a wash step prior to extraction and derivatization and requires 0.5 mL of urine. Benzoylecgonine is extracted in good % recovery at a basic pH by using 4 mL of dichloromethane. The method is accurate and sensitive and allows the quantitation of benzoylecgonine in urine at or below the National Institute on Drug Abuse confirmation cutoff level of 150 ng/mL.


    Paper ID: JFS13525J

    DOI: 10.1520/JFS13525J

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    Title GC/MS Quantitation of Benzoylecgonine Following Liquid-Liquid Extraction of Urine
    Symposium , 0000-00-00
    Committee E30