ISSN: 0022-1198
CODEN: JFSCA
Page Count: 11

The Development of DNA Profiling Database in an HAE III Based RFLP System for Chinese, Malays, and Indians in Singapore
Yap, KH
Technical officer, Institute of Science and Forensic Medicine,

Chow, ST
Scientific officer, Institute of Science and Forensic Medicine,

Ng, TL
Director, Institute of Science and Forensic Medicine,

Tan, WF
Scientific officer, Institute of Science and Forensic Medicine,

(Received 26 August 1992; accepted 16 December 1992)

Abstract

Deoxyribonucleic acid (DNA) restriction fragment length polymorphism (RFLP) profiles were obtained for blood specimens from the three population groups—Chinese, Malays and Indians—in Singapore. The population databases were collected from Hae III digested high molecular weight DNA hybridized with four variable number of tandem repeats (VNTR) loci - D2S44, D10S28, D4S139 and D1S7. The data were analyzed statistically using the fixed bin system. Comparison of ratio of bin frequencies of these population data with published data on whites, blacks, and hispanics shows that the alleleic distribution at these loci is not seriously different among the six groups. This has important implications to the statistical significance of forensic DNA applications.

Keywords:
pathology and biology, Deoxyribonucleic acid (DNA), restriction fragment length polymorphis (RFLP), variable number of tandem repeats (VNTR), allele frequency, paternity index, Chinese, Malays, Indians, binning system, population database

Paper ID: JFS13484J
DOI: 10.1520/JFS13484J
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