Volume 38, Issue 3 (May 1993)

    Opiate Concentrations in Human Head, Axillary, and Public Hair

    (Received 3 April 1992; accepted 3 November 1992)

    CODEN: JFSOAD

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    Abstract

    The concentrations of morphine and codeine were investigated in hair from the head, axillary and public regions obtained from 12 fatal heroin cases. Hair preparation involves a decontamination procedure in dichloromethane at 37°C for 15 min, solubilization in sodium hydroxyde at 100°C for 5 min, neutralization with hydrochloric acid and centrifugation. After extraction in chloroform-isopropanol-n-heptane (50:17:33; v/v) at pH 9.2, drugs were derivatized with BSTFA + 1% TMCS and separated on a 12-m BP-5 capillary column. Quantification was done by GC/MS using selected ion monitoring. The highest morphine concentrations were found in public hair (0.80 to 41.34 ng/mg), followed by hair of the head (0.62 to 27.10 ng/mg), and axillary hair (0.40 to 24.20 ng/mg). Codeine was also detected in all samples, and the codeine-to-morphine ratios ranged from 0.069 to 0.273. The differences observed in drug concentration in the 3 types of hair are discussed in the light of the existing literature.


    Author Information:

    Kintz, P
    Forensic Scientists, Institut de Médecine Légale, Strasbourg,

    Mangin, P
    Forensic Scientists, Institut de Médecine Légale, Strasbourg,


    Stock #: JFS13452J

    ISSN: 0022-1198

    DOI: 10.1520/JFS13452J

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    Author
    Title Opiate Concentrations in Human Head, Axillary, and Public Hair
    Symposium , 0000-00-00
    Committee E30