Volume 38, Issue 2 (March 1993)

    The Structural Identification of a Methyl Analog of Methaqualone via 2-Dimensional NMR Techniques

    (Received 10 July 1992; accepted 7 October 1992)

    CODEN: JFSOAD

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    Abstract

    A submission to the Drug Enforcement Administration North Central Laboratory of a substance believed to be a structural analog of methaqualone hydrochloride precipitated an interest in being able to obtain a rapid and positive identification of such compounds. Both mass spectrometry and proton NMR spectroscopy (1-dimensional) provided evidence to suggest that the structural analog possessed a second methyl group in the molecule, relative to methaqualone, and that the methyl group was attached to the existing methylsubstituted phenyl ring. By application of proton 2-dimensional (2-D) NMR techniques, specifically the homonuclear shift correlation spectroscopy (COSY) and 2-D NOE (NOESY), the precise location of the methyl group in this unknown methaqualone analog was established and shown to have the structure 2.


    Author Information:

    Lankin, DC
    Varian Associates, NMR Application Laboratory, Park Ridge, IL

    Meyers, JA
    Forensic Chemists, U.S. Drug Enforcement Administration, North Central Laboratory, Chicago, IL

    Raney, JK
    Forensic Chemists, U.S. Drug Enforcement Administration, North Central Laboratory, Chicago, IL

    Angelos, SA
    Forensic Chemists, U.S. Drug Enforcement Administration, North Central Laboratory, Chicago, IL


    Stock #: JFS13428J

    ISSN: 0022-1198

    DOI: 10.1520/JFS13428J

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    Title The Structural Identification of a Methyl Analog of Methaqualone via 2-Dimensional NMR Techniques
    Symposium , 0000-00-00
    Committee E30