Nicotine Analysis in Neonates' Hair for Measuring Gestational Exposure to Tobacco

    Volume 38, Issue 1 (January 1993)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Page Count: 5


    Kieffer, I
    Pediatricians, Service de Pédiatrie II, Hôpital de Hautepierre, Strasbourg,

    Messer, J
    Pediatricians, Service de Pédiatrie II, Hôpital de Hautepierre, Strasbourg,

    Kintz, P
    Forensic Toxicologists, Institut de Médecine Légale, Strasbourg,

    Mangin, P
    Forensic Toxicologists, Institut de Médecine Légale, Strasbourg,

    (Received 2 April 1992; accepted 29 April 1992)

    Abstract

    Hair samples were collected at time of delivery from 40 neonates whose mothers were known to be smokers during the prenatal period. Hair was decontaminated in dichloromethane, homogenized in NaOH, and nicotine was extracted in diethyl ether. After separation on a BP-5 capillary column, nicotine was identified and quantified by GC/MS using selected ion monitoring. In all cases, nicotine was found in the neonatal hair and in the hair of the corresponding mother. The ranges of nicotine levels were 0.15 to 11.80 ng/mg, and 0.37 to 63.50 ng/mg, for the neonates, and their mothers, respectively. It was possible to establish a significant correlation between both concentrations, and the correlation coefficient was 0.83. These findings suggest the possibility of monitoring the transfer of maternal nicotine through the placenta by measuring nicotine concentration in neonatal hair.


    Paper ID: JFS13383J

    DOI: 10.1520/JFS13383J

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    Title Nicotine Analysis in Neonates' Hair for Measuring Gestational Exposure to Tobacco
    Symposium , 0000-00-00
    Committee E30