Volume 37, Issue 5 (September 1992)

    The Origin of Alkenes in Illicit Amphetamine: An Examination of the Illicit Synthesis of Phenyl-2-Propanone

    CODEN: JFSOAD

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    Abstract

    The acylative decarboxylation reaction of phenylacetic acid, a method used in clandestine laboratories for the synthesis of phenyl-2-propanone, has been examined. It has been demonstrated that this reaction is accompanied by side-reactions that produce characteristic neutral compounds, some of these are cis and trans 1,3-diphenyl-2-methylpropene and the enol acetates derived from dibenzylketone and phenyl-2-propanone. It would be difficult for an unskilled chemist to separate these neutral substances from phenyl-2-propanone, therefore illicit phenyl-2-propanone is likely to be an impure product. The use of crude phenyl-2-propanone in reductive amination reactions aimed at amphetamine production gives rise to a complex mixture of amines and characteristic neutral compounds.

    The likely origins of N-acetylamphetamine and amphetamine benzaldimine are also discussed.


    Author Information:

    Forbes, IJ
    Post graduate research student with the Department of Applied Chemistry, University of Strathclyde,

    Paul Kirkbride, K
    Senior Forensic Scientist, South Australian State Forensic Science, Adelaide,


    Stock #: JFS13318J

    ISSN: 0022-1198

    DOI: 10.1520/JFS13318J

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    Author
    Title The Origin of Alkenes in Illicit Amphetamine: An Examination of the Illicit Synthesis of Phenyl-2-Propanone
    Symposium , 0000-00-00
    Committee E30