Robotic Method for the Analysis of Morphine and Codeine in Urine

    Volume 37, Issue 5 (September 1992)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Page Count: 12


    Vidal, DL
    Senior Criminalist, Los Angeles County Sheriff's Department, Scientific Services Bureau, Toxicology Section, Los Angeles, CA

    Ting, EJ
    Senior Criminalist, Los Angeles County Sheriff's Department, Scientific Services Bureau, Toxicology Section, Los Angeles, CA

    Taylor, RW
    Senior Criminalist, Los Angeles County Sheriff's Department, Scientific Services Bureau, Toxicology Section, Los Angeles, CA

    Le, SD
    Supervising Criminalist, Los Angeles County Sheriff's Department, Scientific Services Bureau, Toxicology Section,

    Perez, SL
    Criminalistics Laboratory Technician, Los Angeles County Sheriff's Department, Scientific Services Bureau, Toxicology Section,

    (Received 18 November 1991; accepted 30 December 1991)

    Abstract

    A totally automated procedure has been developed for the detection and quantitation of morphine and codeine in urine case samples. The samples were initially screened for these drugs by a SyvaR EMIT Toxicology System (ETS™). A Zymate™ laboratory robotic system confirms positive samples from SyvaR ETS by performing the hydrolysis, extraction, and derivatization of morphine and codeine. The derivatized morphine and codeine were detected using gas chromatography/mass spectrometry (GC/MS). Enzymatic hydrolysis conditions were experimentally optimized during method development. The automation of these procedures has proven to be reliable and efficient.


    Paper ID: JFS13316J

    DOI: 10.1520/JFS13316J

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    Author
    Title Robotic Method for the Analysis of Morphine and Codeine in Urine
    Symposium , 0000-00-00
    Committee E30