Journal Published Online: 01 September 1992
Volume 37, Issue 5

Robotic Method for the Analysis of Morphine and Codeine in Urine

CODEN: JFSCAS

Abstract

A totally automated procedure has been developed for the detection and quantitation of morphine and codeine in urine case samples. The samples were initially screened for these drugs by a SyvaR EMIT Toxicology System (ETS™). A Zymate™ laboratory robotic system confirms positive samples from SyvaR ETS by performing the hydrolysis, extraction, and derivatization of morphine and codeine. The derivatized morphine and codeine were detected using gas chromatography/mass spectrometry (GC/MS). Enzymatic hydrolysis conditions were experimentally optimized during method development. The automation of these procedures has proven to be reliable and efficient.

Author Information

Vidal, DL
Los Angeles County Sheriff's Department, Scientific Services Bureau, Toxicology Section, Los Angeles, CA
Ting, EJ
Los Angeles County Sheriff's Department, Scientific Services Bureau, Toxicology Section, Los Angeles, CA
Perez, SL
Criminalistics Laboratory Technician, Los Angeles County Sheriff's Department, Scientific Services Bureau, Toxicology Section
Taylor, RW
Los Angeles County Sheriff's Department, Scientific Services Bureau, Toxicology Section, Los Angeles, CA
Le, SD
Los Angeles County Sheriff's Department, Scientific Services Bureau, Toxicology Section
Pages: 12
Price: $25.00
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Details
Stock #: JFS13316J
ISSN: 0022-1198
DOI: 10.1520/JFS13316J