Journal Published Online: 01 September 1992
Volume 37, Issue 5

Application of the Combined Use of HPLC/Diode Array Detection and Capillary GC/Nitrogen Phosphorus Detection for the Rapid Analysis of Illicit Heroin and Cocaine Samples

CODEN: JFSCAS

Abstract

A method using a combination of high-performance liquid chromatography and diode array detection (HPLC/DAD) with a methanol/perchlorate buffer pH 2.5 mobile phase and reverse phase C-18 column and capillary gas chromatography with nitrogen phosphorus detection (GC/NPD) has been developed for the rapid, sensitive and accurate analysis of illicit samples of heroin or cocaine. Retention times and UV-spectra were used for the identification of various adulterants and synthetic by-products in street samples. This method is compared with gas-chromatography/mass spectrometry (GC/MS). Forty street samples were analyzed by both methods. It is concluded that the combined use of HPLC/DAD and GC/NPD as a routine analytical procedure for the analysis of illicit samples could be a good alternative to GC/MS for forensic purposes. It is due to their high accessibility and the possibility to perform simultaneously qualitative and quantitative analysis.

Author Information

Hernández, AF
Faculty of Medicine, University of Granada, Granada, Spain
Pla, A
Faculty of Medicine, University of Granada, Granada, Spain
Moliz, J
Laboratory for Instrumental Analysis, University of Granada, Spain
Gil, F
Faculty of Medicine, University of Granada, Granada, Spain
Gonzalvo, MC
Faculty of Medicine, University of Granada, Granada, Spain
Villanueva, E
Faculty of Medicine, University of Granada, Granada, Spain
Pages: 7
Price: $25.00
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Stock #: JFS13315J
ISSN: 0022-1198
DOI: 10.1520/JFS13315J