Volume 37, Issue 5 (September 1992)

    Application of the Combined Use of HPLC/Diode Array Detection and Capillary GC/Nitrogen Phosphorus Detection for the Rapid Analysis of Illicit Heroin and Cocaine Samples

    (Received 30 August 1991; accepted 28 January 1992)

    CODEN: JFSOAD

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    Abstract

    A method using a combination of high-performance liquid chromatography and diode array detection (HPLC/DAD) with a methanol/perchlorate buffer pH 2.5 mobile phase and reverse phase C-18 column and capillary gas chromatography with nitrogen phosphorus detection (GC/NPD) has been developed for the rapid, sensitive and accurate analysis of illicit samples of heroin or cocaine. Retention times and UV-spectra were used for the identification of various adulterants and synthetic by-products in street samples. This method is compared with gas-chromatography/mass spectrometry (GC/MS). Forty street samples were analyzed by both methods. It is concluded that the combined use of HPLC/DAD and GC/NPD as a routine analytical procedure for the analysis of illicit samples could be a good alternative to GC/MS for forensic purposes. It is due to their high accessibility and the possibility to perform simultaneously qualitative and quantitative analysis.


    Author Information:

    Hernández, AF
    Toxicologist, chief toxicologist, toxicologist, Clinical biochemist and chairman, Faculty of Medicine, University of Granada, Granada,

    Pla, A
    Toxicologist, chief toxicologist, toxicologist, Clinical biochemist and chairman, Faculty of Medicine, University of Granada, Granada,

    Villanueva, E
    Toxicologist, chief toxicologist, toxicologist, Clinical biochemist and chairman, Faculty of Medicine, University of Granada, Granada,

    Gil, F
    Toxicologist, chief toxicologist, toxicologist, Clinical biochemist and chairman, Faculty of Medicine, University of Granada, Granada,

    Moliz, J
    Chemist, Laboratory for Instrumental Analysis, University of Granada,

    Gonzalvo, MC
    Toxicologist, chief toxicologist, toxicologist, Clinical biochemist and chairman, Faculty of Medicine, University of Granada, Granada,


    Stock #: JFS13315J

    ISSN: 0022-1198

    DOI: 10.1520/JFS13315J

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    Title Application of the Combined Use of HPLC/Diode Array Detection and Capillary GC/Nitrogen Phosphorus Detection for the Rapid Analysis of Illicit Heroin and Cocaine Samples
    Symposium , 0000-00-00
    Committee E30