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    Volume 37, Issue 2 (March 1992)

    Differentiation of Side Chain Isomers of Ring-Substituted Amphetamines Using Gas Chromatography/Infrared/Mass Spectrometry (GC/IR/MS)

    (Received 9 March 1991; accepted 24 July 1991)

    CODEN: JFSOAD

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    Abstract

    Common analytical methods used for identifying samples obtained from clandestine laboratories were evaluated for their ability to differentiate between possible amphetamine isomers and homologs. A series of ring-substituted (4-methyl, 4-methoxy, and 3,4-methylenedioxy) amphetamine and N-methylphenethylamine isomers was analyzed using color tests, thin-layer chromatography, gas chromatography/mass spectrometry (GC/MS) and GC/infrared (GC/IR). The N-acetyl derivatives of the isomers were analyzed using GC/IR/MS. GC/IR/MS readily differentiated the 4-methylphenylalkylamine isomers. MS and IR spectra were also obtained for each pair of the 4-methoxyphenylalkylamine isomers and the 3,4-methylenedioxyphenylalkylamine isomers, but differentiation via GC/IR/MS was difficult. The N-acetyl derivatives of each pair of isomers could be readily differentiated using GC/IR/MS. Good library researchable spectra for N-acetylamphetamine could be obtained for IR identification with 10 ng (on-column) and MS identification with 2 ng. The spectrometrically independent IR and MS data obtained for the N-acetyl derivatives indicated that the combination of GC/IR/MS can add a significant level of confidence in the analysis of ring-substituted arylalkylamines.


    Author Information:

    O'Neil, DJ
    Drug Analysis Section, Division of Forensic Science, Richmond, VA

    Finley, H
    Drug Analysis Section, Division of Forensic Science, Richmond, VA

    Lambert, R
    Radford University, Radford, VA

    Middleberg, R
    Drug Analysis Section, Division of Forensic Science, Richmond, VA

    Soine, WH
    Virginia Commonwealth University, Richmond, VA

    Duncan, W
    Hewlett-Packard, Scientific Instruments Division, Palo Alto, CA


    Stock #: JFS13259J

    ISSN: 0022-1198

    DOI: 10.1520/JFS13259J

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    Title Differentiation of Side Chain Isomers of Ring-Substituted Amphetamines Using Gas Chromatography/Infrared/Mass Spectrometry (GC/IR/MS)
    Symposium , 0000-00-00
    Committee E30