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    Volume 37, Issue 1 (January 1992)

    Detection of Drugs in Human Hair Using Abbott ADx, with Confirmation by Gas Chromatography/Mass Spectrometry (GC/MS)

    (Received 12 March 1991; accepted 11 June 1991)

    CODEN: JFSOAD

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    Abstract

    The authors suggest use of the fluorescence polarization immunoassay (FPIA) technique in evaluation of chronic drug abuse using human hair.

    Hair was decontaminated in 5 mL of ethanol for 15 min at 37°C and then incubated in 3 mL of 1M sodium hydroxide (NaOH) for 1 h at 100°C. Afterwards, the aliquots were neutralized and analyzed using Abbott ADx for a negative or positive response for the following drugs: benzodiazepines, barbiturates, antidepressants, opiates, cocaine, amphetamine, and cannabis.

    All the positive samples were confirmed by gas chromatography/mass spectrometry (GC/MS). Only one false positive was detected (caused by interference of a phenothiazine with the antidepressants kit), clearly demonstrating the capability of ADx for toxicological screening of human hair.


    Author Information:

    Ludes, B
    Forensic toxicologist, forensic biologist, and forensic toxicologist, respectively, Institut de Medecine Legale, Strasbourg,

    Kintz, P
    Forensic toxicologist, forensic biologist, and forensic toxicologist, respectively, Institut de Medecine Legale, Strasbourg,

    Mangin, P
    Forensic toxicologist, forensic biologist, and forensic toxicologist, respectively, Institut de Medecine Legale, Strasbourg,


    Stock #: JFS13237J

    ISSN: 0022-1198

    DOI: 10.1520/JFS13237J

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    Title Detection of Drugs in Human Hair Using Abbott ADx, with Confirmation by Gas Chromatography/Mass Spectrometry (GC/MS)
    Symposium , 0000-00-00
    Committee E30