ISSN: 0022-1198
CODEN: JFSCA
Page Count: 4

A Rapid Method for the Determination of Cocaine in Brain Tissue
Logan, BK
Chief toxicologist, Washington State Toxicology Laboratory, Department of Laboratory Medicine, University of Washington, WA

Moore, CM
Graduate student, research assistant, graduate student, and assistant professor, University of Illinois at Chicago, IL

Tebbett, IR
Graduate student, research assistant, graduate student, and assistant professor, University of Illinois at Chicago, IL

Scheurer, J
Graduate student, research assistant, graduate student, and assistant professor, University of Illinois at Chicago, IL

Browne, SP
Graduate student, research assistant, graduate student, and assistant professor, University of Illinois at Chicago, IL

(Received 14 February 1991; accepted 19 April 1991)

Abstract

A rapid procedure is described for the extraction and analysis of brain samples for cocaine and benzoylecgonine. Human brain tissue was sectioned at autopsy, and samples were subjected to a lipase digestion, subsequent to solid-phase extraction. The distribution of cocaine and benzoylecgonine throughout different regions of the brain was determined by high-performance liquid chromatography.

Keywords:
toxicology, cocaine, chromatographic analysis, solid-phase extraction, high-performance liquid chromatography

Paper ID: JFS13190J
DOI: 10.1520/JFS13190J
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