ISSN: 0022-1198
CODEN: JFSCA
Page Count: 7

Toxicological Analysis of a Fatal Baclofen (Lioresal) Ingestion
Fraser, AD
Toxicologist, Toxicology Laboratory, Victoria General Hospital, Nova Scotia

Isner, AF
Supervisor and technologist, Toxicology Laboratory, Victoria General Hospital, Nova Scotia

MacNeil, W
Supervisor and technologist, Toxicology Laboratory, Victoria General Hospital, Nova Scotia

(Received 12 January 1991; accepted 15 February 1991)

Abstract

A fatality following ingestion of the drug baclofen (Lioresal®) is described. Baclofen was identified in urine by gas chromatography/mass spectrometry. After derivatization with trinitrobenzene sulfonic acid, baclofen was quantitated in serum and urine by high-performance liquid chromatography. The concentration of baclofen was 17 mg/L in serum and 760 mg/L in urine collected approximately 12 h after the overdose. To our knowledge, this is only the second reported fatality involving a baclofen overdose. The previous case did not include quantitation of baclofen in any biological fluid.

Keywords:
toxicology, baclofen, death, chromatographic analysis, drug overdoses

Paper ID: JFS13182J
DOI: 10.1520/JFS13182J
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