Toxicological Analysis of a Fatal Baclofen (Lioresal) Ingestion

    Volume 36, Issue 5 (September 1991)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Page Count: 7


    Fraser, AD
    Toxicologist, Toxicology Laboratory, Victoria General Hospital, Halifax, Nova Scotia

    Isner, AF
    Supervisor and technologist, Toxicology Laboratory, Victoria General Hospital, Halifax, Nova Scotia

    MacNeil, W
    Supervisor and technologist, Toxicology Laboratory, Victoria General Hospital, Halifax, Nova Scotia

    (Received 12 January 1991; accepted 15 February 1991)

    Abstract

    A fatality following ingestion of the drug baclofen (Lioresal®) is described. Baclofen was identified in urine by gas chromatography/mass spectrometry. After derivatization with trinitrobenzene sulfonic acid, baclofen was quantitated in serum and urine by high-performance liquid chromatography. The concentration of baclofen was 17 mg/L in serum and 760 mg/L in urine collected approximately 12 h after the overdose. To our knowledge, this is only the second reported fatality involving a baclofen overdose. The previous case did not include quantitation of baclofen in any biological fluid.


    Paper ID: JFS13182J

    DOI: 10.1520/JFS13182J

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    Author
    Title Toxicological Analysis of a Fatal Baclofen (Lioresal) Ingestion
    Symposium , 0000-00-00
    Committee E30