Chloroquine Distribution in Postmortem Cases

    Volume 36, Issue 5 (September 1991)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Page Count: 8


    Levine, B
    Chief toxicologist, Division of Forensic Toxicology, Armed Forces Institute of Pathology, Washington, DC

    Wagner, GN
    Captain, U.S. Navy, and deputy chief medical examiner, Office of the Armed Forces Medical Examiner, Armed Forces Institute of Pathology, Washington, DC

    Kuhlman, JJ
    Major, U.S. Air Force, and deputy chief toxicologist, Division of Forensic Toxicology, Armed Forces Institute of Pathology, Washington, DC

    Smith, ML
    Lieutenant colonel, U.S. Army, and chief, Division of Forensic Toxicology, Armed Forces Institute of Pathology, Washington, DC

    Mayes, RW
    Squadron leader, Royal Air Force, and chief toxicologist, R.A.F. Institute of Pathology and Tropical Medicine, Aylesbury, Bucks,

    Jones, R
    Toxicologist, Division of Forensic Toxicology, Armed Forces Institute of Pathology, Washington, DC

    (Received 10 September 1990; accepted 27 December 1990)

    Abstract

    Chloroquine concentrations in blood and tissues were examined in overdose and non-overdose cases to determine appropriate ranges for interpretation. Twenty-nine literature overdose cases and 8 non-overdose literature cases were compared with this laboratory's findings. The results indicate significant postmortem redistribution of chloroquine. Combining this laboratory's results and the literature results indicates that using a liver concentration of 150 mg/kg as a cutoff between overdose and non-overdose concentrations properly identified 30 of the 34 published cases containing liver chloroquine and 19 of the 20 presented cases.


    Paper ID: JFS13178J

    DOI: 10.1520/JFS13178J

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    Author
    Title Chloroquine Distribution in Postmortem Cases
    Symposium , 0000-00-00
    Committee E30