Journal Published Online: 01 September 1991
Volume 36, Issue 5

Detection, Isolation, and Identification of Truxillines in Illicit Cocaine by Means of Thin-Layer Chromatography and Mass Spectrometry

CODEN: JFSCAS

Abstract

By means of thin-layer chromatography, an unidentified alkaloidal fraction was observed in illicit cocaine. Because of its persisting presence, efforts were undertaken to isolate and identify this fraction. Various analytical techniques showed complex results, finally pointing to the possibility of isomerization of constituents of the fraction. A direct-probe mass spectrum showed a fragmentation pattern which could only fit a truxilline. When using thin-layer chromatography, at least five isomers could be observed. This is the first time truxillines have been observed, isolated, and identified by thin-layer chromatography.

Author Information

Ensing, JG
University Centre for Pharmacy, University of Groningen, Groningen, The Netherlands
de Zeeuw, RA
University Centre for Pharmacy, University of Groningen, Groningen, The Netherlands
Pages: 13
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Stock #: JFS13153J
ISSN: 0022-1198
DOI: 10.1520/JFS13153J