Detection, Isolation, and Identification of Truxillines in Illicit Cocaine by Means of Thin-Layer Chromatography and Mass Spectrometry

    Volume 36, Issue 5 (September 1991)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Page Count: 13


    Ensing, JG
    University Centre for Pharmacy, University of Groningen, Groningen,

    de Zeeuw, RA
    Professor of toxicology, University Centre for Pharmacy, University of Groningen, Groningen,

    (Received 8 November 1990; accepted 28 January 1991)

    Abstract

    By means of thin-layer chromatography, an unidentified alkaloidal fraction was observed in illicit cocaine. Because of its persisting presence, efforts were undertaken to isolate and identify this fraction. Various analytical techniques showed complex results, finally pointing to the possibility of isomerization of constituents of the fraction. A direct-probe mass spectrum showed a fragmentation pattern which could only fit a truxilline. When using thin-layer chromatography, at least five isomers could be observed. This is the first time truxillines have been observed, isolated, and identified by thin-layer chromatography.


    Paper ID: JFS13153J

    DOI: 10.1520/JFS13153J

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    Title Detection, Isolation, and Identification of Truxillines in Illicit Cocaine by Means of Thin-Layer Chromatography and Mass Spectrometry
    Symposium , 0000-00-00
    Committee E30