(Received 10 July 1990; accepted 26 October 1990)
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Polymorphic genetic loci of the deoxyribonucleic acid (DNA) present in formalin-fixed, paraffin-embedded tissues were successfully analyzed by utilizing the polymerase chain reaction. Using this analysis, with three different polymorphic loci [human leucocyte antigen (HLA) DQ alpha, low-density lipoprotein receptor, and parathyroid hormone], fixed tissues representing 14 different individuals were genotyped and could be distinguished from each other. The techniques were further applied to the fixed autopsy tissues of a man in which a question of paternity arose postmortem. Since many individuals have surgical procedures or autopsy, these readily available fixed tissues represent an additional resource for the identification of individuals.
Assistant professor of pathology, University of Southern California School of Medicine and Los Angeles County + University of Southern California Medical Center, Los Angeles, CA
Visiting scholar in forensic medicine from the Department of Legal Medicine, Nippon Medical School, Tokyo,
Professor of pathology, University of Southern California School of Medicine and Los Angeles County + University of Southern California Medical Center, Los Angeles, CA
Stock #: JFS13137J