Volume 36, Issue 4 (July 1991)

    Benzoylecgonine (Cocaine Metabolite) Detection in Hair Samples of Jail Detainees Using Radioimmunoassay (RIA) and Gas Chromatography/Mass Spectrometry (GC/MS)

    (Received 27 August 1990; accepted 17 December 1990)

    CODEN: JFSOAD

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    Abstract

    Benzoylecgonine (BE) was detected in hair samples using nonproprietary extraction methodology and modifications of well-established radioimmunoassay (RIA) screening/quantitative gas chromatography/mass spectrometry (GC/MS) confirmation procedures. Samples collected anonymously from a population of 48 jail detainees weighed between 5.3 and 61.2 mg. All of the 22 hair samples which had RIA results indicating the presence of BE or immunologically similar substances above a cutoff amount of 1.25 ng/sample (50 ng/mL) were confirmed by GC/MS. Several varieties of hair color and texture were tested, although in each general category there were samples which contained BE as well as other samples which did not reveal detectable amounts of BE. The range of concentrations in 22 hair extracts that screened positive were 0.26 to 18 ng/mg hair as determined by GC/MS. In comparison with other reports of cocaine-related substances in hair, these data show consistent concentrations.


    Author Information:

    Smith, FP
    Fulbright Research Scholar, University of Strathclyde, Glasgow, Scotland, AL

    Reuschel, SA
    Graduate student, University of Alabama at Birmingham, Birmingham, AL


    Stock #: JFS13133J

    ISSN: 0022-1198

    DOI: 10.1520/JFS13133J

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    Author
    Title Benzoylecgonine (Cocaine Metabolite) Detection in Hair Samples of Jail Detainees Using Radioimmunoassay (RIA) and Gas Chromatography/Mass Spectrometry (GC/MS)
    Symposium , 0000-00-00
    Committee E30