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    Volume 36, Issue 1 (January 1991)

    A Comparison of Three Computer Models for Prediction of Dose in Acute Amitriptyline Overdose

    (Received 5 October 1989; accepted 1 February 1990)

    CODEN: JFSOAD

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    Abstract

    The pharmacokinetics of amitriptyline in overdose have been reported not to fit conventional compartmental models. In this study, the dose-concentration-time relationships of amitriptyline in overdose were modeled with discriminant analysis, with an evolutionary heuristic search program, and with a decision-tree model based on the entropy of uncertainty of classification. The computer models all used the same data from dogs administered treatment (80 mg/kg), toxic (250 mg/kg), or fatal (500 mg/kg) doses directly into the surgically isolated duodenum. All the models achieved a high degree of success (77 to 93%) in assigning records to the high-, low-, or middle-dose groups. Two of the models gave a probability of the assignment. Results of this analysis suggest that blood amitriptyline and nortriptyline concentrations are most useful in estimating dose in acute amitriptyline overdose.


    Author Information:

    Wimbish, G
    Associate professor and director, Institute of Forensic Medicine, and associate professor of medical education, Texas College of Osteopathic Medicine, Fort Worth, TX

    Shores, J
    Associate professor and director, Institute of Forensic Medicine, and associate professor of medical education, Texas College of Osteopathic Medicine, Fort Worth, TX

    Spiehler, V
    Technical director, Diagnostic Products Corp., Los Angeles, CA


    Stock #: JFS13016J

    ISSN: 0022-1198

    DOI: 10.1520/JFS13016J

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    Title A Comparison of Three Computer Models for Prediction of Dose in Acute Amitriptyline Overdose
    Symposium , 0000-00-00
    Committee E30