Volume 35, Issue 6 (November 1990)

    Capillary Gas-Liquid Chromatography Separation of Phenethylamines in Amphetamine-Positive Urine Samples

    (Received 21 August 1989; accepted 14 December 1989)

    CODEN: JFSOAD

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    Abstract

    Good gas chromatography (GC) separation of molecules is essential for clean gas chromatography/mass spectrometry (GC/MS) confirmation of compounds. The trifluoro derivatives of ephedrine (E) and methamphetamine (MA) coelute on dimethyl silicone capillary columns, such as DB-1, which are most commonly used by chromatographers. Methods are described to separate E and MA to aid GC/MS confirmations of methamphetamine, ephedrine, or both E and MA together, whichever may be present in Enzyme Immunoassay (EIA)-analyzed amphetamine-positive urine samples. The use of the heptafluoro derivatives of E and MA on a DB-1 column, or the trifluoro derivatives of E and MA on a DB-17 column, is suggested for good gas chromatographic separation.


    Author Information:

    DePace, A
    Research scientist, New York State Psychiatric Institute, New York, NY

    Verebey, K
    Director of toxicology, New York City Department of Health, New York, NY

    ElSohly, M
    Director, ElSohly Laboratories, Inc., Oxford, MS


    Stock #: JFS12979J

    ISSN: 0022-1198

    DOI: 10.1520/JFS12979J

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    Author
    Title Capillary Gas-Liquid Chromatography Separation of Phenethylamines in Amphetamine-Positive Urine Samples
    Symposium , 0000-00-00
    Committee E30