ISSN: 0022-1198
CODEN: JFSCA
Page Count: 9

Paternity Testing: Blood Group Systems and DNA Analysis by Variable Number of Tandem Repeat Markers
Akane, A
Forensic scientists and professor, Shimane Medical University,

Shiono, H
Forensic scientists and professor, Shimane Medical University,

Yuasa, I
Assistant professor, Tottori University, School of Medicine,

Matsubara, K
Forensic scientists and professor, Shimane Medical University,

Yamada, M
Medical geneticists, National Children's Medical Research Center,

Yokota, S-I
Medical geneticists, National Children's Medical Research Center,

Nakagome, Y
Medical geneticists, National Children's Medical Research Center,

(Received 22 July 1989; accepted 29 September 1989)

Abstract

Two recent paternity cases are reported. In the first case of paternity exclusion, deoxyribonucleic acid (DNA) restriction fragment length polymorphisms (RFLPs) on variable number of tandem repeat (VNTR) loci with multiple alleles were informative, as well as established systems of red blood antigens, red cell enzymes, serum proteins, and human leukocyte antigens. In the second case, in which both the alleged father and the first wife were deceased, the paternal genotype was determined by using genetic markers from the second wife and four children, which then were compared with the paternal alleles of the child in question, the plaintiff in this case. The high probability of paternity (0.999 998 7) made us conclude that the man probably was the actual father. The DNA analysis by VNTR probes appears to be quite valuable in the study of paternity cases.

Keywords:
pathology and biology, paternity, genetic markers, variable number of tandem repeat (VNTR) markers, paternity testing, deoxyribonucleic acid (DNA) analysis

Paper ID: JFS12948J
DOI: 10.1520/JFS12948J
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