Volume 35, Issue 4 (July 1990)

    Interlaboratory Reproducibility of Retention Indices in Capillary Gas Chromatography

    (Received 6 June 1989; accepted 11 July 1989)

    CODEN: JFSOAD

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    Abstract

    Because of the temperature-dependent behavior of Kovat's retention indices (RI), based on straight-chain alkane homologues and a liquid phase such as SE-30. OV-1. or methyl silicone, the interlaboratory reproducibility of these RIs determined on capillary columns is comparable to those determined on packed columns. Other homologue series investigated—including diisopropyl-n-alkylamines (DIPA), tri-n-alkylamines (TAA), and 1-nitro-n-alkanes (NIA)—showed the same phenomenon. However, by using a carefully selected reference drug mixture, a dramatic gain in the interlaboratory reproducibility of RI values can be obtained, even under vastly different operational conditions. This allows a search window of ±25 RI units for capillary methyl silicone columns, which is much better than the ±60 RI units that must be applied when using alkane or substituted alkane homologues.


    Author Information:

    Franke, J-P
    Senior research associate, research associate, and professor of toxicology, University Center for Pharmacy, Groningen,

    Wijsbeek, J
    Senior research associate, research associate, and professor of toxicology, University Center for Pharmacy, Groningen,

    de Zeeuw, RA
    Senior research associate, research associate, and professor of toxicology, University Center for Pharmacy, Groningen,


    Stock #: JFS12893J

    ISSN: 0022-1198

    DOI: 10.1520/JFS12893J

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    Author
    Title Interlaboratory Reproducibility of Retention Indices in Capillary Gas Chromatography
    Symposium , 0000-00-00
    Committee E30