ISSN: 0022-1198
CODEN: JFSCA
Page Count: 14

Some Effects of Mechanical Trauma on the Development of Primary Cancers and Their Metastases
Weiss, L
Chief cancer research clinician, Roswell Park Memorial Institute, NY

(Received 24 February 1989; accepted 6 June 1989)

Abstract

Posttraumatic inflammation and, much less commonly, mechanical trauma itself may affect the clinical course of cancer. There is no evidence that a single incident of trauma can cause cancer, although posttraumatic chronic inflammation may be associated with carcinogenesis. In patients with cancer at the time of trauma, inflammation and repair processes may inhibit or enhance cancer growth, and trauma and its sequelae may increase the rates of invasion and dissemination.

Keywords:
pathology and biology, cancer, injuries, carcinogenesis, invasion, mechanical trauma, metastasis

Paper ID: JFS12867J
DOI: 10.1520/JFS12867J
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