Journal Published Online: 01 May 1990
Volume 35, Issue 3

Behavior of Genetic Markers in Recipients After Bone Marrow Transplantation and Problems in Forensic Medicine

CODEN: JFSCAS

Abstract

The authors report studies on four pairs of donors and recipients in bone marrow transplantation (BMT). A broad range of gene markers at 41 gene loci, including 11 red blood cell markers, 5 human lymphocyte antigen (HLA) types, 12 serum protein markers, 5 red cell enzyme markers, and 8 salivary markers were evaluated before and after BMT over 2 months. As a result, 9 out of 41 gene loci of genetic markers in recipients were transformed into the donor type. BMT between family members may lead to transformation of gene markers, but within a pattern compatible with family inheritance patterns, and no genetic paradox will be found in later surveys of familial genetic relationships. However, in a personal identification system in forensic medicine using genetic markers as an index, the appearance of a phenotype incompatible with a blood relationship is possible after BMT with a non-blood-relative donor. This result is similar to the inheritance pattern observed after artificial insemination by a donor's semen (AID), a more complete out-of-family cross.

Author Information

Ikemoto, S
Jichi Medical School, Tochigi, Japan
Kajii, E
Jichi Medical School, Tochigi, Japan
Tsuchida, S
Jichi Medical School, Tochigi, Japan
Amemiya, Y
Jichi Medical School, Tochigi, Japan
Kato, K
Tottori Central Hospital, Tottori, Japan
Miura, Y
Jichi Medical School, Tochigi, Japan
Pages: 6
Price: $25.00
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Stock #: JFS12860J
ISSN: 0022-1198
DOI: 10.1520/JFS12860J