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    Volume 35, Issue 3 (May 1990)

    Behavior of Genetic Markers in Recipients After Bone Marrow Transplantation and Problems in Forensic Medicine

    (Received 10 April 1989; accepted 8 July 1989)

    CODEN: JFSOAD

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    Abstract

    The authors report studies on four pairs of donors and recipients in bone marrow transplantation (BMT). A broad range of gene markers at 41 gene loci, including 11 red blood cell markers, 5 human lymphocyte antigen (HLA) types, 12 serum protein markers, 5 red cell enzyme markers, and 8 salivary markers were evaluated before and after BMT over 2 months. As a result, 9 out of 41 gene loci of genetic markers in recipients were transformed into the donor type. BMT between family members may lead to transformation of gene markers, but within a pattern compatible with family inheritance patterns, and no genetic paradox will be found in later surveys of familial genetic relationships. However, in a personal identification system in forensic medicine using genetic markers as an index, the appearance of a phenotype incompatible with a blood relationship is possible after BMT with a non-blood-relative donor. This result is similar to the inheritance pattern observed after artificial insemination by a donor's semen (AID), a more complete out-of-family cross.


    Author Information:

    Kajii, E
    Professor and immunohematologists, Jichi Medical School, Tochigi,

    Kato, K
    Vice director, Tottori Central Hospital, Tottori,

    Ikemoto, S
    Professor and immunohematologists, Jichi Medical School, Tochigi,

    Tsuchida, S
    Professor and immunohematologists, Jichi Medical School, Tochigi,

    Amemiya, Y
    Associate professor and professor, Jichi Medical School, Tochigi,

    Miura, Y
    Associate professor and professor, Jichi Medical School, Tochigi,


    Stock #: JFS12860J

    ISSN: 0022-1198

    DOI: 10.1520/JFS12860J

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    Title Behavior of Genetic Markers in Recipients After Bone Marrow Transplantation and Problems in Forensic Medicine
    Symposium , 0000-00-00
    Committee E30