An Improved Method for Complement Subcomponent C1R Typing

    Volume 35, Issue 1 (January 1990)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Page Count: 3


    Kamboh, MI
    Assistant professor and professor, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA

    Ferrell, RE
    Assistant professor and professor, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA

    (Received 6 September 1988; accepted 27 January 1989)

    Abstract

    An improved method has been developed for the reliable classification of different C1R genetic variant forms from human serum or plasma. The method combines the use of neuraminidase-digested samples followed by monodimensional isoelectric focusing in the pH range 5 to 8 followed by immunoblotting. The method yields a simple pattern, with one major band in homozygote and two major bands in heterozygote cases.


    Paper ID: JFS12817J

    DOI: 10.1520/JFS12817J

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    Author
    Title An Improved Method for Complement Subcomponent C1R Typing
    Symposium , 0000-00-00
    Committee E30