ISSN: 0022-1198
CODEN: JFSCA
Page Count: 10

Isotopic Analog as the Internal Standard for Quantitative Determination: Evaluation of Mass Spectra of Commonly Abused Drugs and Their Deuterated Analogs
Nichols, AW
Senior staff scientist and senior scientist, Radian Corporation, TX

Liu, RH
Research associate and professor, University of Alabama at Birmingham, AL

Kumar, SD
Senior staff scientist and senior scientist, Radian Corporation, TX

Ho, YS
Research associate and professor, University of Alabama at Birmingham, AL

(Received 2 February 1989; accepted 15 March 1989)

Abstract

Mass spectra of several commonly abused drugs and their deuterated analogs are compared and evaluated with emphasis on the selection of suitable ions for selective ion monitoring when the isotopic analogs are used as the internal standards in a quantitative determination process. Ions selected for this purpose should be of relative high mass with significant intensities, retain at least three labeling isotopes, and be free of interference from the corresponding compound.

Keywords:
toxicology, abuse drugs, internal standard, analogs, chemical analysis, amphetamine, methamphetamine, cocaine, benzoylecgonine, methadone, codeine, morphine, phencyclidine, 9-carboxy-11-nor-delta-9-tetrahydrocannabinol

Paper ID: JFS12809J
DOI: 10.1520/JFS12809J
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