Volume 34, Issue 5 (September 1989)
A Review of Analytical Procedures for Therapeutic Drug Monitoring and Emergency Toxicology, 2nd ed.
This is the second edition of a popular laboratory procedures manual first published in 1980. The volume retains the same format as the original work. Drugs or classes of drugs commonly analyzed for in therapeutic monitoring or clinical toxicology are indexed in alpha-betical order with one or more specific procedures for their analysis in blood, plasma, serum, and/or urine presented. Each procedure includes: the principle of the method, necessary reagents and their preparation, instrumental conditions, extraction protocol, calculation of results, performance characteristics, and possible interferences with the assay. The directions are well written, clear, concise, and easy to follow. Should the analyst wish to inquire further, at least one reference is presented for each procedure. One hundred seventy-four procedures for the analysis of one hundred and one drugs are presented. Unfortunately, only IS of these are new additions to the 1980 first edition. The remaining 159 procedures are exactly as previously published reflecting 1970s technologies (for example, packed gas chromatographic [GC] columns, flame ionization detectors [FID]).