Journal Published Online: 01 July 1989
Volume 34, Issue 4

Isotopic Analogue as the Internal Standard for Quantitative Determination of Benzoylecgonine: Concerns with Isotopic Purity and Concentration Level

CODEN: JFSCAS

Abstract

Empirical data is used to demonstrate the observation and quantification of benzoylecgonine in negative test samples when high concentrations of deuterated benzoylecgonine are used as the internal standard in the assay process. On the quantitative determination of true positive samples, inaccuracy introduced by the isotopic impurity of the internal standard is calculated as a function of the impurity and the concentration levels of the internal standard used.

Author Information

Liu, RH
University of Alabama at Birmingham, Birmingham, AL
Diane Baugh, L
University of Alabama at Birmingham, Birmingham, AL
Ellen Allen, E
University of Alabama at Birmingham, Birmingham, AL
Salud, SC
Environmental Health Research and Testing, Inc., Birmingham, AL
Fentress, JG
Environmental Health Research and Testing, Inc., Birmingham, AL
Chadha, H
Environmental Health Research and Testing, Inc., Birmingham, AL
Walia, AS
University of Alabama at Birmingham, School of Medicine, Birmingham, AL
Pages: 5
Price: $25.00
Related
Reprints and Permissions
Reprints and copyright permissions can be requested through the
Copyright Clearance Center
Details
Stock #: JFS12725J
ISSN: 0022-1198
DOI: 10.1520/JFS12725J