Volume 34, Issue 4 (July 1989)

    Isotopic Analogue as the Internal Standard for Quantitative Determination of Benzoylecgonine: Concerns with Isotopic Purity and Concentration Level

    (Received 16 September 1988; accepted 18 October 1988)

    CODEN: JFSOAD

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    Abstract

    Empirical data is used to demonstrate the observation and quantification of benzoylecgonine in negative test samples when high concentrations of deuterated benzoylecgonine are used as the internal standard in the assay process. On the quantitative determination of true positive samples, inaccuracy introduced by the isotopic impurity of the internal standard is calculated as a function of the impurity and the concentration levels of the internal standard used.


    Author Information:

    Walia, AS
    Chief, Alcoholism Research, VA Medical Center, and research associate professor, University of Alabama at Birmingham, School of Medicine, Birmingham, AL

    Ellen Allen, E
    Associate professor, graduate student, and former graduate student, University of Alabama at Birmingham, Birmingham, AL

    Chadha, H
    Laboratory manager, GC/MS technician, and GC/MS technician, Environmental Health Research and Testing, Inc., Birmingham, AL

    Fentress, JG
    Laboratory manager, GC/MS technician, and GC/MS technician, Environmental Health Research and Testing, Inc., Birmingham, AL

    Diane Baugh, L
    Associate professor, graduate student, and former graduate student, University of Alabama at Birmingham, Birmingham, AL

    Liu, RH
    Associate professor, graduate student, and former graduate student, University of Alabama at Birmingham, Birmingham, AL

    Salud, SC
    Laboratory manager, GC/MS technician, and GC/MS technician, Environmental Health Research and Testing, Inc., Birmingham, AL


    Stock #: JFS12725J

    ISSN: 0022-1198

    DOI: 10.1520/JFS12725J

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    Author
    Title Isotopic Analogue as the Internal Standard for Quantitative Determination of Benzoylecgonine: Concerns with Isotopic Purity and Concentration Level
    Symposium , 0000-00-00
    Committee E30