Volume 34, Issue 3 (May 1989)

    The Differentiation of Lysergic Acid Diethylamide (LSD) from N-Methyl-N-Propyl and N-Butyl Amides of Lysergic Acid

    (Received 28 June 1988; accepted 25 August 1988)

    CODEN: JFSOAD

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    Abstract

    The N-methyl-N-propyl, N-methyl-N-isopropy, N-butyl, N-isobutyl, N-sec-butyl and N-tert-butyl amides of lysergic acid were synthesized to determine the specificity of electron impact mass spectroscopy (EI/MS), when combined with other analytical techniques, for the identification of lysergic acid diethylamide (LSD). After separation of the C8 axial and equatorial isomers by preparative thin-layer chromatography, the amides were subjected to gas-liquid chromatography (GLC), thin-layer chromatography (TLC), high pressure liquid chromatography (HPLC), and EI/MS. EI/MS, when combined with other analytical techniques, is shown to be capable of differentiating LSD from any of the other compounds included in this study.


    Author Information:

    Clark, CC
    Forensic chemist, U.S. Drug Enforcement Administration, Southeast Laboratory, Miami, FL


    Stock #: JFS12674J

    ISSN: 0022-1198

    DOI: 10.1520/JFS12674J

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    Author
    Title The Differentiation of Lysergic Acid Diethylamide (LSD) from N-Methyl-N-Propyl and N-Butyl Amides of Lysergic Acid
    Symposium , 0000-00-00
    Committee E30