Journal Published Online: 01 May 1989
Volume 34, Issue 3

The Differentiation of Lysergic Acid Diethylamide (LSD) from -Methyl- -Propyl and -Butyl Amides of Lysergic Acid

CODEN: JFSCAS

Abstract

The N-methyl-N-propyl, N-methyl-N-isopropy, N-butyl, N-isobutyl, N-sec-butyl and N-tert-butyl amides of lysergic acid were synthesized to determine the specificity of electron impact mass spectroscopy (EI/MS), when combined with other analytical techniques, for the identification of lysergic acid diethylamide (LSD). After separation of the C8 axial and equatorial isomers by preparative thin-layer chromatography, the amides were subjected to gas-liquid chromatography (GLC), thin-layer chromatography (TLC), high pressure liquid chromatography (HPLC), and EI/MS. EI/MS, when combined with other analytical techniques, is shown to be capable of differentiating LSD from any of the other compounds included in this study.

Author Information

Clark, CC
U.S. Drug Enforcement Administration, Southeast Laboratory, Miami, FL
Pages: 15
Price: $25.00
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Stock #: JFS12674J
ISSN: 0022-1198
DOI: 10.1520/JFS12674J