Journal Published Online: 01 March 1989
Volume 34, Issue 2

Tissue Distribution of Cocaine in a Pregnant Woman

CODEN: JFSCAS

Abstract

Reports of cocaine-related obstetrical problems, including abruptio placentae and spontaneous abortion, have become increasingly evident in the medical literature; however, little is known about tissue distribution of cocaine in the pregnant woman. We report the toxicologic results of distribution studies performed on a pregnant woman and her fetus. Maternal/fetal cocaine concentration ratios were high when comparing blood (9:1), brain (6:5), and kidney (10:6). Possible explanations of the mechanism for lower fetal cocaine concentrations may include uterine vasoconstriction, incomplete maternal/fetal equalibration, or rapid placental, fetal clearance.

Author Information

Mittleman, RE
University of Miami School of Medicine, Miami, FL
Cofino, JC
Dade County Medical Examiner Department, Miami, FL
Hearn, WL
University of Miami School of Medicine, Miami, FL
Pages: 6
Price: $25.00
Related
Reprints and Permissions
Reprints and copyright permissions can be requested through the
Copyright Clearance Center
Details
Stock #: JFS12662J
ISSN: 0022-1198
DOI: 10.1520/JFS12662J