Volume 34, Issue 1 (January 1989)

    Changes in the Specificity of Blood Groups Induced by Enzymes from Soil Fungi

    (Received 22 July 1987; accepted 15 March 1988)

    CODEN: JFSOAD

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    Abstract

    Three strains of Cunninghamella elegance (C. elegance), Penicillium simplicissimum (P. simpl.), and Aspergillus niger (A. niger) were isolated from soil that produced the enzymes acting on blood groups A and B red cells. Culture filtrates from these fungi contained α-N-acetyl-D-galactosaminidase as an A-decomposing enzyme, which resulted in an almost complete loss of A specificity and an enhancement of blood group H activity as measured by elution tests using monoclonal antibodies. They also contained an α-D-galactosidase and an α-L-fucosidase, which partially destroyed the blood group B specific activity, but did not influence the blood group H specific activity.


    Author Information:

    Kubo, S
    Graduate student of medicine, Nagasaki University School of Medicine, Nagasaki,


    Stock #: JFS12615J

    ISSN: 0022-1198

    DOI: 10.1520/JFS12615J

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    Author
    Title Changes in the Specificity of Blood Groups Induced by Enzymes from Soil Fungi
    Symposium , 0000-00-00
    Committee E30