ISSN: 0022-1198
CODEN: JFSCA
Page Count: 9

Changes in the Specificity of Blood Groups Induced by Enzymes from Soil Fungi
Kubo, S
Graduate student of medicine, Nagasaki University School of Medicine,

(Received 22 July 1987; accepted 15 March 1988)

Abstract

Three strains of Cunninghamella elegance (C. elegance), Penicillium simplicissimum (P. simpl.), and Aspergillus niger (A. niger) were isolated from soil that produced the enzymes acting on blood groups A and B red cells. Culture filtrates from these fungi contained α-N-acetyl-D-galactosaminidase as an A-decomposing enzyme, which resulted in an almost complete loss of A specificity and an enhancement of blood group H activity as measured by elution tests using monoclonal antibodies. They also contained an α-D-galactosidase and an α-L-fucosidase, which partially destroyed the blood group B specific activity, but did not influence the blood group H specific activity.

Keywords:
pathology and biology, blood, fungi, soils, blood group substance, monoclonal antibody

Paper ID: JFS12615J
DOI: 10.1520/JFS12615J
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