Volume 33, Issue 4 (July 1988)
Tissue Distribution of Ethosuximide and Clobazam in a Seizure Related Fatality
The case of a six-year-old male who died in a hospital while receiving several anti-convulsant drugs is described. Phenytoin, desmethyldiazepam, clobazam (an experimental 1,5 benzodiazepine), and desmethylclobazam were quantitated in serum, liver, and brain tissue by high performance liquid chromatography. Ethosuximide was quantitated by gas chromatography. To our knowledge, this is one of few reports describing tissue concentrations of ethosuximide collected at autopsy and the first report of clobazam/desmethylclobazam tissue distribution in man.