ISSN: 0022-1198
CODEN: JFSCA
Page Count: 6

Tissue Distribution of Ethosuximide and Clobazam in a Seizure Related Fatality
Fraser, AD
Head, Dalhousie University, Nova Scotia

Isner, AF
Chemist, Toxicology Laboratory, Victoria General Hospital, Nova Scotia

Heifetz, SA
Pathologist, Department of Pathology, Izaak Walton Killam Hospital for Children, Nova Scotia

(Received 7 July 1987; accepted 16 September 1987)

Abstract

The case of a six-year-old male who died in a hospital while receiving several anti-convulsant drugs is described. Phenytoin, desmethyldiazepam, clobazam (an experimental 1,5 benzodiazepine), and desmethylclobazam were quantitated in serum, liver, and brain tissue by high performance liquid chromatography. Ethosuximide was quantitated by gas chromatography. To our knowledge, this is one of few reports describing tissue concentrations of ethosuximide collected at autopsy and the first report of clobazam/desmethylclobazam tissue distribution in man.

Keywords:
pathology and biology, epilepsy, ethosuximide, clobazam, chromatographic analysis

Paper ID: JFS12532J
DOI: 10.1520/JFS12532J
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