Tissue Distribution of Ethosuximide and Clobazam in a Seizure Related Fatality

    Volume 33, Issue 4 (July 1988)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Page Count: 6


    Fraser, AD
    Head, Dalhousie University, Halifax, Nova Scotia

    Isner, AF
    Chemist, Toxicology Laboratory, Victoria General Hospital, Halifax, Nova Scotia

    Heifetz, SA
    Pathologist, Department of Pathology, Izaak Walton Killam Hospital for Children, Halifax, Nova Scotia

    (Received 7 July 1987; accepted 16 September 1987)

    Abstract

    The case of a six-year-old male who died in a hospital while receiving several anti-convulsant drugs is described. Phenytoin, desmethyldiazepam, clobazam (an experimental 1,5 benzodiazepine), and desmethylclobazam were quantitated in serum, liver, and brain tissue by high performance liquid chromatography. Ethosuximide was quantitated by gas chromatography. To our knowledge, this is one of few reports describing tissue concentrations of ethosuximide collected at autopsy and the first report of clobazam/desmethylclobazam tissue distribution in man.


    Paper ID: JFS12532J

    DOI: 10.1520/JFS12532J

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    Author
    Title Tissue Distribution of Ethosuximide and Clobazam in a Seizure Related Fatality
    Symposium , 0000-00-00
    Committee E30