ISSN: 0022-1198
CODEN: JFSCA
Page Count: 10

The Identification of Nitromethaqualone and Its Differentiation from Some Positional Isomers
Clark, CC
Forensic chemist, Drug Enforcement Administration, Southeast Laboratory, FL

(Received 8 August 1987; accepted 20 October 1987)

Abstract

Nitromethaqualone [2-methyl-3(2′-methoxy-4′-nitrophenyl)-4(3H)-quinazolinone] and its three positional isomers formed by moving the nitro group on the phenyl ring containing the 2′-methoxyl group have been synthesized and characterized. Mass spectra, infrared spectra, nuclear magnetic resonance spectra, and the gas-liquid chromatographic behavior of these compounds are presented. It is shown that infrared spectroscopy, nuclear magnetic resonance spectroscopy, and electron impact mass spectroscopy combined with gas-liquid chromatography are capable of differentiating nitromethaqualone from any of the studied isomers, methaqualone, and mecloqualone.

Keywords:
toxicology, nitromethaqualone, chemical analysis, methaqualone, mecloqualone

Paper ID: JFS12528J
DOI: 10.1520/JFS12528J
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