Volume 33, Issue 4 (July 1988)
The Identification of Nitromethaqualone and Its Differentiation from Some Positional Isomers
Nitromethaqualone [2-methyl-3(2′-methoxy-4′-nitrophenyl)-4(3H)-quinazolinone] and its three positional isomers formed by moving the nitro group on the phenyl ring containing the 2′-methoxyl group have been synthesized and characterized. Mass spectra, infrared spectra, nuclear magnetic resonance spectra, and the gas-liquid chromatographic behavior of these compounds are presented. It is shown that infrared spectroscopy, nuclear magnetic resonance spectroscopy, and electron impact mass spectroscopy combined with gas-liquid chromatography are capable of differentiating nitromethaqualone from any of the studied isomers, methaqualone, and mecloqualone.