A Fatality Involving Clomipramine

    Volume 31, Issue 2 (April 1986)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Page Count: 6


    Fraser, AD
    Head, Toxicology Laboratory, Victoria General Hospital, Halifax, Nova Scotia

    Isner, AF
    Chemist, Toxicology Laboratory, Victoria General Hospital, Halifax, Nova Scotia

    Moss, MA
    Office of the Chief Medical Examiner, Province of Nova Scotia, Department of Attorney General, Halifax, Nova Scotia, Canada and Director, Division of Clinical Chemistry, Dalhousie University, Halifax, Nova Scotia

    (Received 26 March 1985; accepted 10 July 1985)

    Abstract

    A fatality following ingestion of the tricyclic antidepressant clomipramine (Anafranil®), alprazolam (Xanax®), and ethyl alcohol is described. Clomipramine and N-desmethylclomipramine were quantitated by high performance liquid chromatography and alprazolam by gas liquid chromatography. Concentrations of clomipramine and N-desmethylclomipramine were: in blood—0.84 and 1.4 mg/L; in urine—0.56 and 0.62 mg/L. Alprazolam concentration in blood was 0.069 mg/L. Ethyl alcohol was measured by headspace gas chromatography and found to be 375, 385, and 435 mg/dL in blood, urine, and vitreous humor, respectively. These findings are compared to previous reports of clomipramine related fatalities and alprazolam toxicity combined with ethyl alcohol.


    Paper ID: JFS12312J

    DOI: 10.1520/JFS12312J

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    Author
    Title A Fatality Involving Clomipramine
    Symposium , 0000-00-00
    Committee E30