ISSN: 0022-1198
CODEN: JFSCA
Page Count: 12

Profiles of Δ⁹-Tetrahydrocannabinol Metabolites in Urine of Marijuana Users: Preliminary Observations by High Performance Liquid Chromatography-Radioimmunoassay
Peat, MA
Codirector, Chemical Toxicology, Institute, CA

Alburges, ME
Graduate student, University of Utah, UT

(Received 20 April 1985; accepted 10 August 1985)

Abstract

Metabolic profiles of 11-nor-9-carboxylic acid-Δ⁹-tetrahydrocannabinol (COOH-THC) and other THC metabolites were determined in an infrequent and a frequent marijuana user by high performance liquid chromatography-radioimmunoassay (HPLC-RIA). In the infrequent user, no unconjugated COOH-THC was detected in urine samples for the first 8 h following smoking, whereas this metabolite was detected in the urine samples from a frequent user. A metabolite was also detected in the frequent user, which was not present in the urine sample from the infrequent user.

Keywords:
toxicology, tetrahydrocannabinol, marijuana, chromatographic analysis, urine

Paper ID: JFS12302J
DOI: 10.1520/JFS12302J
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