Codirector, Chemical Toxicology, Institute, Foster City, CA
Graduate student, University of Utah, Salt Lake City, UT
(Received 20 April 1985; accepted 10 August 1985)
Metabolic profiles of 11-nor-9-carboxylic acid-Δ9-tetrahydrocannabinol (COOH-THC) and other THC metabolites were determined in an infrequent and a frequent marijuana user by high performance liquid chromatography-radioimmunoassay (HPLC-RIA). In the infrequent user, no unconjugated COOH-THC was detected in urine samples for the first 8 h following smoking, whereas this metabolite was detected in the urine samples from a frequent user. A metabolite was also detected in the frequent user, which was not present in the urine sample from the infrequent user.
Paper ID: JFS12302J