(Received 20 April 1985; accepted 10 August 1985)
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Metabolic profiles of 11-nor-9-carboxylic acid-Δ9-tetrahydrocannabinol (COOH-THC) and other THC metabolites were determined in an infrequent and a frequent marijuana user by high performance liquid chromatography-radioimmunoassay (HPLC-RIA). In the infrequent user, no unconjugated COOH-THC was detected in urine samples for the first 8 h following smoking, whereas this metabolite was detected in the urine samples from a frequent user. A metabolite was also detected in the frequent user, which was not present in the urine sample from the infrequent user.
Codirector, Chemical Toxicology, Institute, Foster City, CA
Graduate student, University of Utah, Salt Lake City, UT
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