Volume 28, Issue 1 (January 1983)

    Analysis of Blood and Tissue for Amoxapine and Trimipramine

    (Received 13 March 1982; accepted 2 June 1982)

    Published Online: January

    CODEN: JFSOAD

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    Abstract

    A method for the identification and quantitation of two tricyclic antidepressants, amoxapine (Asendin®) and trimipramine (Surmontil®) is presented here. Samples were extracted with hexane at pH 10, back-extracted with 1.0N sulfuric acid. The acidic layer was adjusted to pH 10 and re-extracted with hexane. Electron impact mass spectra were obtained. The base peak and molecular ion for amoxapine were at m/z 245 and 313, respectively. The base peak and molecular ion for trimipramine were at m/z 58 and 294, respectively. There were three forensic toxicology cases involving amoxapine in Cook County, IL, in 1980 and 1981. The concentrations of amoxapine in blood for these three cases were 1.66 mg/L, 7.16 mg/L, and 2.95 mg/L, respectively.


    Author Information:

    Hadac, JP
    Toxicologist and GC/MS section chief, chief toxicologist, assistant chief toxicologist, toxicologist, and chief medical examiner, Cook County Institute of Forensic Medicine, Office of the Medical Examiner, Chicago, IL

    Schaffer, MI
    Toxicologist and GC/MS section chief, chief toxicologist, assistant chief toxicologist, toxicologist, and chief medical examiner, Cook County Institute of Forensic Medicine, Office of the Medical Examiner, Chicago, IL

    Wu Chen, NB
    Toxicologist and GC/MS section chief, chief toxicologist, assistant chief toxicologist, toxicologist, and chief medical examiner, Cook County Institute of Forensic Medicine, Office of the Medical Examiner, Chicago, IL

    Lin, R-L
    Toxicologist and GC/MS section chief, chief toxicologist, assistant chief toxicologist, toxicologist, and chief medical examiner, Cook County Institute of Forensic Medicine, Office of the Medical Examiner, Chicago, IL

    Stein, RJ
    Toxicologist and GC/MS section chief, chief toxicologist, assistant chief toxicologist, toxicologist, and chief medical examiner, Cook County Institute of Forensic Medicine, Office of the Medical Examiner, Chicago, IL


    Stock #: JFS12244J

    ISSN: 0022-1198

    DOI: 10.1520/JFS12244J

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    Author
    Title Analysis of Blood and Tissue for Amoxapine and Trimipramine
    Symposium , 0000-00-00
    Committee E30