Journal Published Online: 01 January 1983
Volume 28, Issue 1

Postmortem Stability of Benzodiazepines in Blood and Tissues

CODEN: JFSCAS

Abstract

The stability of benzodiazepines in blood and tissues was examined in this study. Specifically, diazepam, chlordiazepoxide, flurazepam, and their desalkyl metabolites were studied over several months. Diazepam, flurazepam, and N-1-desalkylflurazepam were stable when stored in blood at room temperature while chlordiazepoxide, norchlordiazepoxide, and nordiazepam were found to be unstable under similar storage conditions. Data from tissues containing these chemicals corroborated the results from blood.

Author Information

Levine, B
Medical College of Virginia, Virginia Commonwealth University, Richmond, VA
Blanke, RV
Toxicology Laboratory, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA
Valentour, JC
Medical College of Virginia, Virginia Commonwealth University, Richmond, VA
Pages: 14
Price: $25.00
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Stock #: JFS12243J
ISSN: 0022-1198
DOI: 10.1520/JFS12243J