The Preparation of d-Pseudococaine from l-Cocaine

    Volume 25, Issue 2 (April 1980)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Published Online: 1 April 1980

    Page Count: 9


    Siegel, JA
    Assistant professors, Metropolitan State College, Denver, Colo

    Cormier, RA
    Assistant professors, Metropolitan State College, Denver, Colo

    (Received 18 May 1979; accepted 31 October 1979)

    Abstract

    d-Pseudococaine, a diastereoisomer of cocaine, is prepared from l-cocaine by the action of strong base that epimerizes the carbomethoxy group at C-2 to the equatorial position and transesterifies the ester at C-3. The benzoate ester is regenerated by reaction with benzoyl chloride. The d-pseudococaine thus prepared is then subjected to a variety of instrumental and analytical techniques to effect its characterization. The tests done are those commonly used in forensic science laboratories for cocaine analysis. With these data, a laboratory can eliminate or confirm pseudococaine in such an analysis.


    Paper ID: JFS12136J

    DOI: 10.1520/JFS12136J

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    Author
    Title The Preparation of d-Pseudococaine from l-Cocaine
    Symposium , 0000-00-00
    Committee E30