Volume 44, Issue 5 (September 1999)

    Gene and Genotype Frequencies for HLA-DQA1 in Caucasians and Mulattoes in Brazil

    (Received 17 September 1998; accepted 1 February 1999)

    CODEN: JFSOAD

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    Abstract

    Gene and genotype frequencies of the HLA-DQA1 locus were determined in a sample of 197 unrelated individuals (144 Caucasians and 53 Mulattoes), living in the city of São Paulo, Brazil. The Mulatto group consisted of mixed individuals who presented at least one negroid physical characteristic or declared themselves to be of mixed ancestry. A total of six different alleles were identified with frequencies ranging from 0.087 to 0.316 in the Caucasian population and from 0.066 to 0.330 in the Mulatto population. We observed an increased frequency of allele 1.2 among Mulattoes in relation to Caucasians. The sample heterozygote frequency was 0.722 among Caucasians and 0.736 among Mullatoes. No significant deviations from Hardy-Weinberg equilibrium were found either in the Caucasian or in the Brazilian Mullato population samples.


    Author Information:

    Billerbeck, AEC
    Laboratorio de Pesquisa da 1a Clinica Médica do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo,

    Muñoz, DR
    Faculdade de Medicina, Universidade de Universidade de São Paulo, Brasil Instituto Oscar Freire, São Paulo,

    Iwamura, ESM
    Faculdade de Medicina, Universidade de Universidade de São Paulo, Brasil Instituto Oscar Freire, São Paulo,

    Soares-Vieira, JA
    Faculdade de Medicina, Universidade de Universidade de São Paulo, Brasil Instituto Oscar Freire, São Paulo,

    Otto, PA
    Instituto de Biociências, Universidade de São Paulo,


    Stock #: JFS12040J

    ISSN: 0022-1198

    DOI: 10.1520/JFS12040J

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    Author
    Title Gene and Genotype Frequencies for HLA-DQA1 in Caucasians and Mulattoes in Brazil
    Symposium , 0000-00-00
    Committee E30