ISSN: 0022-1198
CODEN: JFSCA
Page Count: 5

Graphical Tools for RFLP Measurement Quality Assurance: Laboratory Performance Charts
Reeder, DJ
Biotechnology Division, Chemical Science and Technology Laboratory, National Institute of Standards and Technology, MD

Duewer, DL
Analytical Chemistry Division, Chemical Science and Technology Laboratory, National Institute of Standards and Technology, MD

Gary, KT
Biotechnology Division, Chemical Science and Technology Laboratory, National Institute of Standards and Technology, MD

(Received 6 October 1998; accepted 25 January 1999)

Abstract

Forensic restriction fragment length polymorphism analyses typically provide two band size results at each genetic locus for each sample. In collaboration with the member laboratories of the Technical Working Group for DNA Analysis Methods, we have developed graphical techniques that compactly summarize even large numbers of such paired measurements. This paper provides a detailed description of the basic tool, a modified bivariate control chart for data from multiple samples and/or multiple loci. We demonstrate how various modifications and combinations of these “laboratory performance charts” can be used for quality control, quality assurance, and quality demonstration.

Keywords:
forensic science, DNA profiling, graphical analysis, interlaboratory comparison, proficiency testing, quality control, TWGDAM

Paper ID: JFS12026J
DOI: 10.1520/JFS12026J
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