Graphical Tools for RFLP Measurement Quality Assurance: Single-Locus Charts

    Volume 44, Issue 5 (September 1999)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Page Count: 9


    Reeder, DJ
    Biotechnology Division, Chemical Science and Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, MD

    Duewer, DL
    Analytical Chemistry Division, Chemical Science and Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, MD

    Liu, H-K
    Statistical Engineering Division, Information Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, MD

    (Received 15 May 1998; accepted 25 January 1999)

    Abstract

    Forensic restriction fragment length polymorphism analyses typically provide two results for each sample, one result for each unique allele, at each genetic locus probed. In collaboration with the member laboratories of the Technical Working Group for DNA Analysis Methods, we have developed graphical techniques that compactly summarize even large numbers of such paired measurements. This paper provides a detailed description of the basic tool, a modified bivariate control chart for data from one sample at one locus. We demonstrate how various modifications and combinations of these “single-locus charts” can be used for within- and among-laboratory quality assurance activities.


    Paper ID: JFS12025J

    DOI: 10.1520/JFS12025J

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    Author
    Title Graphical Tools for RFLP Measurement Quality Assurance: Single-Locus Charts
    Symposium , 0000-00-00
    Committee E30