Journal Published Online: 01 September 1999
Volume 44, Issue 5

Graphical Tools for RFLP Measurement Quality Assurance: Single-Locus Charts

CODEN: JFSCAS

Abstract

Forensic restriction fragment length polymorphism analyses typically provide two results for each sample, one result for each unique allele, at each genetic locus probed. In collaboration with the member laboratories of the Technical Working Group for DNA Analysis Methods, we have developed graphical techniques that compactly summarize even large numbers of such paired measurements. This paper provides a detailed description of the basic tool, a modified bivariate control chart for data from one sample at one locus. We demonstrate how various modifications and combinations of these “single-locus charts” can be used for within- and among-laboratory quality assurance activities.

Author Information

Duewer, DL
Analytical Chemistry Division, Chemical Science and Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, MD
Liu, H-K
Statistical Engineering Division, Information Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, MD
Reeder, DJ
Biotechnology Division, Chemical Science and Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, MD
Pages: 9
Price: $25.00
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Stock #: JFS12025J
ISSN: 0022-1198
DOI: 10.1520/JFS12025J