1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP): One Designer Drug and Serendipity

    Volume 33, Issue 2 (March 1988)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Published Online: 1 March 1988

    Page Count: 8


    Weingarten, HL
    Forensic toxicologist, Santa Clara County Laboratory of Criminalistics, San Jose, CA

    Abstract

    Through an unlikely series of coincidences and fortunate accidents, the development of Parkinson's disease in several illicit drug users was traced to their use of a meperidine analog contaminated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The discovery of a chemical capable of producing animal models of the disease has revitalized research efforts and resulted in important new information. The serendipitous finding also prompted consideration of what changes seem advisable if designer drugs are to be dealt with more efficaciously.


    Paper ID: JFS11978J

    DOI: 10.1520/JFS11978J

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    Title 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP): One Designer Drug and Serendipity
    Symposium , 0000-00-00
    Committee E30