Volume 33, Issue 2 (March 1988)

    1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP): One Designer Drug and Serendipity

    Published Online: March

    CODEN: JFSOAD

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    Abstract

    Through an unlikely series of coincidences and fortunate accidents, the development of Parkinson's disease in several illicit drug users was traced to their use of a meperidine analog contaminated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The discovery of a chemical capable of producing animal models of the disease has revitalized research efforts and resulted in important new information. The serendipitous finding also prompted consideration of what changes seem advisable if designer drugs are to be dealt with more efficaciously.


    Author Information:

    Weingarten, HL
    Forensic toxicologist, Santa Clara County Laboratory of Criminalistics, San Jose, CA


    Stock #: JFS11978J

    ISSN: 0022-1198

    DOI: 10.1520/JFS11978J

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    Author
    Title 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP): One Designer Drug and Serendipity
    Symposium , 0000-00-00
    Committee E30