A Fatality Involving U4Euh, A Cyclic Derivative of Phenylpropanolamine

Volume 33, Issue 2 (March 1988)

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ISSN: 0022-1198
CODEN: JFSCA
Published Online: 1 March 1988
Page Count: 5

A Fatality Involving U4Euh, A Cyclic Derivative of Phenylpropanolamine
Davis, FT
Senior chemist, Orlando Crime Laboratory, FL

Brewster, ME
Associate director of research, Pharmatec, Inc., FL

(Received 30 March 1987; accepted 1 June 1987)

Abstract

A fatality following ingestion of diazepam and 4,5-dihydro-4-methyl-5-phenyl-2-oxazolamine, a cyclic derivative of phenylpropanolamine known as U4EuH or 4-methyl aminorex, is described. Solid dosage samples of U4EuH were analyzed using gas chromatography, ultraviolet and infrared spectroscopy, nuclear magnetic resonance, and mass spectrometry. Physiological fluids were analyzed quantitatively by gas chromatography and qualitatively by gas chromatography-mass spectrometry. Concentrations of 4,5-dihydro-4-methyl-5-phenyl-2-oxazolamine were: in blood 21.3 mg/L; in urine 12.3 mg/L. Diazepam concentration in blood was 0.8 mg/L.

Keywords:
toxicology, 4-methyl aminorex (U4EuH), chemical analysis

Paper ID: JFS11971J
DOI: 10.1520/JFS11971J
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Author Title A Fatality Involving U4Euh, A Cyclic Derivative of Phenylpropanolamine Symposium , 0000-00-00 Committee E30

		SEDL / Journals / Journal of Forensic Sciences (JOFS) / Citation Page Volume 33, Issue 2 (March 1988) Click here to download this paper now for $25 PDF (352K) View License Agreement ISSN: 0022-1198 CODEN: JFSCA Published Online: 1 March 1988 Page Count: 5 A Fatality Involving U4Euh, A Cyclic Derivative of Phenylpropanolamine Davis, FT Senior chemist, Orlando Crime Laboratory, FL Brewster, ME Associate director of research, Pharmatec, Inc., FL (Received 30 March 1987; accepted 1 June 1987) Abstract A fatality following ingestion of diazepam and 4,5-dihydro-4-methyl-5-phenyl-2-oxazolamine, a cyclic derivative of phenylpropanolamine known as U4EuH or 4-methyl aminorex, is described. Solid dosage samples of U4EuH were analyzed using gas chromatography, ultraviolet and infrared spectroscopy, nuclear magnetic resonance, and mass spectrometry. Physiological fluids were analyzed quantitatively by gas chromatography and qualitatively by gas chromatography-mass spectrometry. Concentrations of 4,5-dihydro-4-methyl-5-phenyl-2-oxazolamine were: in blood 21.3 mg/L; in urine 12.3 mg/L. Diazepam concentration in blood was 0.8 mg/L. Keywords: toxicology, 4-methyl aminorex (U4EuH), chemical analysis Paper ID: JFS11971J DOI: 10.1520/JFS11971J ASTM International is a member of CrossRef. Author Title A Fatality Involving U4Euh, A Cyclic Derivative of Phenylpropanolamine Symposium , 0000-00-00 Committee E30