A Fatality Involving U4Euh, A Cyclic Derivative of Phenylpropanolamine

    Volume 33, Issue 2 (March 1988)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Published Online: 1 March 1988

    Page Count: 5


    Davis, FT
    Senior chemist, Orlando Crime Laboratory, Orlando, FL

    Brewster, ME
    Associate director of research, Pharmatec, Inc., Alachua, FL

    (Received 30 March 1987; accepted 1 June 1987)

    Abstract

    A fatality following ingestion of diazepam and 4,5-dihydro-4-methyl-5-phenyl-2-oxazolamine, a cyclic derivative of phenylpropanolamine known as U4EuH or 4-methyl aminorex, is described. Solid dosage samples of U4EuH were analyzed using gas chromatography, ultraviolet and infrared spectroscopy, nuclear magnetic resonance, and mass spectrometry. Physiological fluids were analyzed quantitatively by gas chromatography and qualitatively by gas chromatography-mass spectrometry. Concentrations of 4,5-dihydro-4-methyl-5-phenyl-2-oxazolamine were: in blood 21.3 mg/L; in urine 12.3 mg/L. Diazepam concentration in blood was 0.8 mg/L.


    Paper ID: JFS11971J

    DOI: 10.1520/JFS11971J

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    Title A Fatality Involving U4Euh, A Cyclic Derivative of Phenylpropanolamine
    Symposium , 0000-00-00
    Committee E30