(Received 6 June 1985; accepted 18 July 1985)
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The discovery of dulcin, the second synthetic sweetener, has been traced to the work of J. Berlinerblau. Early studies of this sweetener revealed a very effective sweetener that showed toxicity at high doses. Dulcin never achieved great recognition nor usage but was utilized slightly until a long-term study clearly pointed out its toxicity under sustained use with small doses.
Professor of chemistry, St. Mary's College of Maryland, St. Mary's City, MD
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