A Clandestine Approach to the Synthesis of Phenyl-2-Propanone from Phenylpropenes

    Volume 29, Issue 4 (October 1984)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Page Count: 22


    Raney, JK
    Senior forensic chemist, forensic chemist, and forensic chemist, Drug Enforcement Administration, North Central Laboratory, Chicago, IL

    Angelos, SA
    Senior forensic chemist, forensic chemist, and forensic chemist, Drug Enforcement Administration, North Central Laboratory, Chicago, IL

    Dal Cason, TA
    Senior forensic chemist, forensic chemist, and forensic chemist, Drug Enforcement Administration, North Central Laboratory, Chicago, IL

    (Received 11 February 1984; accepted 14 March 1984)

    Abstract

    A number of published syntheses for the manufacture of controlled substances appear to be impractical for the average clandestine laboratory. A closer inspection of these syntheses may reveal modifications which greatly simplify their application. An excellent example of this is the preparation of phenyl-2-propanone (P-2-P) from allylbenzene. In the prototype published method, oxygen is introduced into the reaction vessel by using a tank of compressed oxygen with a balloon for a gas reservoir. In our modification, oxidation is accomplished with a 30% hydrogen peroxide solution. P-2-P has been prepared by both methods and a comparison made of the reaction mixtures at various times during their synthesis. Additionally, propenylbenzene, a by-product of these reactions, can be converted to P-2-P by modification of a second synthesis. Gas chromatography and nuclear magnetic resonance spectral data are presented for each method.


    Paper ID: JFS11789J

    DOI: 10.1520/JFS11789J

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    Title A Clandestine Approach to the Synthesis of Phenyl-2-Propanone from Phenylpropenes
    Symposium , 0000-00-00
    Committee E30