ISSN: 0022-1198
CODEN: JFSCA
Page Count: 7

Detection of Methamphetamine and Amphetamine in a Single Human Hair by Gas Chromatography/Chemical Ionization Mass Spectrometry
Hattori, H
Associate professor, research associate, and professor, Hamamatsu University School of Medicine,

Asano, M
Associate professor, research associate, and professor, Hamamatsu University School of Medicine,

Suzuki, O
Associate professor, research associate, and professor, Hamamatsu University School of Medicine,

(Received 23 April 1983; accepted 2 July 1983)

Abstract

A detailed procedure of an extremely sensitive method for quantitation of methamphetamine and amphetamine in human hair by gas chromatography (GC)/chemical ionization (CI) mass spectrometry (MS) is presented. N-methylbenzylamine was used as an internal standard. The samples, after extraction with an organic solvent, were derivatized with trifluoroacetic anhydride before the GC/MS analysis. Quantitation was made with quasi-molecular ions of the derivatives by selected ion monitoring in the CI mode. The detection limit was about 10 pg in an injected volume. The high sensitivity enabled us to measure both stimulants in a single human hair in actual cases.

Keywords:
toxicology, methamphetamine, amphetamine, hair, gas ehromatography/chemical ionization mass spectrometry

Paper ID: JFS11712J
DOI: 10.1520/JFS11712J
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