ISSN: 0022-1198
CODEN: JFSCA
Page Count: 8

Differentiation of Side Chain Positional Isomers of Amphetamine
Agee, DT
Regional laboratory supervisor, undergraduate intern, and supervisor, Drug Examination Section, Bureau of Forensic Science, Consolidated Laboratories of Virginia, VA

Scott, J
Regional laboratory supervisor, undergraduate intern, and supervisor, Drug Examination Section, Bureau of Forensic Science, Consolidated Laboratories of Virginia, VA

Thomas, MN
Assistant professor and undergraduate research assistant, School of Pharmacy Medical College of Virginia/Virginia Commonwealth University, VA

Shark, RE
Regional laboratory supervisor, undergraduate intern, and supervisor, Drug Examination Section, Bureau of Forensic Science, Consolidated Laboratories of Virginia, VA

Soine, WH
Assistant professor and undergraduate research assistant, School of Pharmacy Medical College of Virginia/Virginia Commonwealth University, VA

(Received 2 February 1983; accepted 11 April 1983)

Abstract

The eleven side chain positional isomers of amphetamine can be distinguished using a combination of color tests, thin-layer chromatography, and mass spectrometry. The primary amines, 1-phenylpropylamine and β-methylphenethylamine, exhibited chromatographic behavior similar to amphetamine but were readily differentiated using mass spectrometry. The mass spectra of N-methylphenethylamine was very similar to amphetamine, but using color tests and chromatography it was readily differentiated from amphetamine.

Keywords:
toxicology, amphetamine, chromatographic analysis, positional isomers, mass spectrometry

Paper ID: JFS11649J
DOI: 10.1520/JFS11649J
ASTM International is a member of CrossRef.