Chief of neurology, Veterans Administration Medical Center, Iowa City, IA
Associate professor, State University of New York at Buffalo, Buffalo, NY
Assistant professor, College of Pharmacy University of Iowa, Iowa City, IA
Director, Rocky Mountain Laboratories, Colorado Springs, CO
(Received 29 March 1983; accepted 17 May 1983)
The postabsorptive distribution of cimetidine is described. Assays by high pressure liquid chromatography (HPLC) of postmortem samples of cerebrospinal fluid, serum, and solid tissues were used to determine pharmacokinetic parameters as well as mean tissue: serum concentration (T:S) ratios in seven patients with renal and liver dysfunction. Correlations were calculated between the T:S ratio and the volume of distribution, and between the T:S concentration ratio and the time of sampling after death. The highest T:S ratios occurred in the eliminating organs, the liver and kidneys, and the lowest in fat. As the time of autopsy increased after death, the T:S ratios decreased.
Paper ID: JFS11645J