ISSN: 0022-1198
CODEN: JFSCA
Published Online: 1 October 1983
Page Count: 7

The Determination of Cocaine and Its Major Metabolite, Benzoylecgonine, in Postmortem Fluids and Tissues by Computerized Gas Chromatography/Mass Spectrometry
Griesemer, EC
Supervising criminalist, senior criminalist, and medical examiner, Los Angeles County Medical Examiner-Coroner, CA

Raftogianis, L
Mass spectroscopist, Finnigan Corp., CA

Budd, RD
Supervising criminalist, senior criminalist, and medical examiner, Los Angeles County Medical Examiner-Coroner, CA

Noguchi, TT
Supervising criminalist, senior criminalist, and medical examiner, Los Angeles County Medical Examiner-Coroner, CA

Liu, Y
Fellow in toxicology, Forensic Sciences Institute, Ministry of Public Security,

(Received 24 January 1983; accepted 28 February 1983)

Abstract

An analytical procedure for the simultaneous determination of both cocaine and benzoylecgonine in postmortem fluid and tissue samples has been developed by using computerized gas chromatography/mass spectrometry and gas chromatography using a nitrogen/phosphorus (N/P) detector. Both methods are accurate and sensitive and allow the determination of tissue concentrations of cocaine and benzoylecgonine as low as 0.015 μg/mL.

Keywords:
toxicology, cocaine, chemical analysis

Paper ID: JFS11597J
DOI: 10.1520/JFS11597J
ASTM International is a member of CrossRef.