Identification of Some Interferences in the Analysis of Clorazepate

    Volume 28, Issue 3 (July 1983)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Published Online: 1 July 1983

    Page Count: 28


    Suzuki, EM
    Criminalists, Chemical Analysis Unit, Criminalistics Section, Crime Laboratory System, Washington State Patrol, Seattle, WA

    Gresham, WR
    Criminalists, Chemical Analysis Unit, Criminalistics Section, Crime Laboratory System, Washington State Patrol, Seattle, WA

    (Received 2 November 1982; accepted 13 December 1982)

    Abstract

    Clorazepate presents several problems in identification. In addition to rapid acid decarboxylation to N-desmethyldiazepam, a noncontrolled substance often confused with clorazepate, extracts of the pharmaceutical forms (Tranxene and Azenez capsules) contain substances that interfere with isolation of intact and unaltered clorazepate. These substances have been identified and have been found to be quite dependent on both capsule type and, especially, on capsule age. The cause of the conversion of dipotassium clorazepate to the monopotassium salt, following solution, has also been identified. An infrared analysis method, which removes all of the interferences, is presented.


    Paper ID: JFS11562J

    DOI: 10.1520/JFS11562J

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    Title Identification of Some Interferences in the Analysis of Clorazepate
    Symposium , 0000-00-00
    Committee E30