Volume 28, Issue 3 (July 1983)

    Identification of Some Interferences in the Analysis of Clorazepate

    (Received 2 November 1982; accepted 13 December 1982)

    Published Online: July

    CODEN: JFSOAD

      Format Pages Price  
    PDF Version 28 $25   ADD TO CART


    Abstract

    Clorazepate presents several problems in identification. In addition to rapid acid decarboxylation to N-desmethyldiazepam, a noncontrolled substance often confused with clorazepate, extracts of the pharmaceutical forms (Tranxene and Azenez capsules) contain substances that interfere with isolation of intact and unaltered clorazepate. These substances have been identified and have been found to be quite dependent on both capsule type and, especially, on capsule age. The cause of the conversion of dipotassium clorazepate to the monopotassium salt, following solution, has also been identified. An infrared analysis method, which removes all of the interferences, is presented.


    Author Information:

    Suzuki, EM
    Criminalists, Chemical Analysis Unit, Criminalistics Section, Crime Laboratory System, Washington State Patrol, Seattle, WA

    Gresham, WR
    Criminalists, Chemical Analysis Unit, Criminalistics Section, Crime Laboratory System, Washington State Patrol, Seattle, WA


    Stock #: JFS11562J

    ISSN: 0022-1198

    DOI: 10.1520/JFS11562J

    ASTM International
    is a member of CrossRef.

    Author
    Title Identification of Some Interferences in the Analysis of Clorazepate
    Symposium , 0000-00-00
    Committee E30