Accidental Digoxin Overdose in an Infant: Postmortem Tissue Concentrations

    Volume 28, Issue 2 (April 1983)

    ISSN: 0022-1198

    CODEN: JFSOAD

    Published Online: 1 April 1983

    Page Count: 7


    Hastreiter, AR
    Professor of pediatrics, University of Illinois Hospital Medical Center, Chicago, IL

    Kim, PW
    Pediatrician, Mount Prospect, IL

    van der Horst, R
    Associate professor of pediatrics, University of Illinois Medical Center, Chicago, IL

    (Received 7 June 1982; accepted 25 August 1982)

    Abstract

    We report the digoxin concentration in various tissues of a seven-week-old infant who died 45 min after receiving an accidental intravenous overdose of digoxin. The digoxin content of various organs was calculated and expressed as a percentage of dose administered. The literature of accidental massive digoxin overdose in infants has been reviewed. Data on tissue concentrations and distribution of digoxin in this age group is scarce. The concentration of digoxin in myocardium, kidney, liver, and other organs observed in our case rank among the highest ever reported in human tissues.


    Paper ID: JFS11532J

    DOI: 10.1520/JFS11532J

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    Title Accidental Digoxin Overdose in an Infant: Postmortem Tissue Concentrations
    Symposium , 0000-00-00
    Committee E30