ISSN: 0022-1198
CODEN: JFSCA
Published Online: 1 January 1982
Page Count: 12

Applicability of Capillary Gas Chromatography to Substance Identification in Toxicology by Means of Retention Indices
Franke, JP
Research associate, research associate, senior research associate, and professor of toxicology, State University,

Wijsbeek, J
Research associate, research associate, senior research associate, and professor of toxicology, State University,

Schepers, P
Research associate, research associate, senior research associate, and professor of toxicology, State University,

de Zeeuw, RA
Research associate, research associate, senior research associate, and professor of toxicology, State University,

(Received 3 March 1981; accepted 8 June 1981)

Abstract

Three capillary columns, set up in a routine screening system, were tested in temperature-programmed runs. A narrow-bore fused silica capillary, Carbowax deactivated and with a methylsilicone liquid phase, was found to be unstable at higher temperatures, giving irreproducible results and retention indices that varied considerably from those obtained on packed columns. The two other columns, a wide-bore glass capillary and a narrow-bore fused silica capillary, were polysiloxane-deactivated and had a dimethylpolysiloxane liquid phase. Although both showed good stability, reproducibility, and load capacity, retention indices for various drugs still showed discrepancies as compared to corresponding values on packed columns.

Keywords:
toxicology, chromatographic analysis, drug identification, systematic drug screening, capillary gas chromatography, retention indices

Paper ID: JFS11450J
DOI: 10.1520/JFS11450J
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